The immune mechanism of the mTOR/ACC1/CPT1A fatty acid oxidation signaling pathway in Hashimoto’s thyroiditis
The mTOR/ACC1/CPT1A fatty acid oxidation pathway of CD4<sup>+</sup>T cells in Hashimoto's thyroiditis was increased, and treatment with Etomoxir could inhibit the activation of this pathway, and reverse the reprogramming of abnormal metabolism in CD4<sup>+</sup>T cells, thereby reducing Hashimoto's thyroiditis.
Authors
- Mengfan He (ORCID: https://orcid.org/0000-0002-2866-9887)
- Lu Zhang (ORCID: https://orcid.org/0000-0002-3139-2356)
- Xingjie Xie
- Haixia Liu (ORCID: https://orcid.org/0000-0002-0529-0428)
- Baohua Wang (ORCID: https://orcid.org/0000-0001-6327-2626)
- Yanyan Liu (ORCID: https://orcid.org/0009-0005-3808-8962)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Journal of Endocrinological Investigation
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1007/s40618-024-02501-4
- Citations
- 2
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Dalian Science and Technology Bureau
- Dalian Medical University
- Dalian Science and Technology Innovation Fund