The Role of Fibrinogen in Mediating NGAL-Associated Neuronal Damage in Acute Ischemic Stroke: A Moderated Mediation Analysis
The NGAL levels were associated with NSE, and the NGAL-associated neuronal damage might be partially mediated by fibrinogen, suggesting that the inflammatory response among NGAL, fibrinogen, and NSE should be intervened to reduce neuronal damage after ischemic stroke. Further animal experiments are needed to clarify their specific mechanisms and precise relationships.
Authors
- Jie Ding (ORCID: https://orcid.org/0000-0002-0016-1141)
- Desheng Zhu (ORCID: https://orcid.org/0000-0003-2454-2173)
- Yangtai Guan (ORCID: https://orcid.org/0000-0003-0813-4073)
- Yaying Song (ORCID: https://orcid.org/0000-0002-3154-1235)
- Lu Han (ORCID: https://orcid.org/0000-0002-9912-1384)
- Zhongjiao Lu (ORCID: https://orcid.org/0000-0003-3347-4352)
- Nan Zhao (ORCID: https://orcid.org/0000-0001-5153-9063)
- Yi Chen (ORCID: https://orcid.org/0000-0002-4966-8365)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Punan Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s495788
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Baoshan Science and Technology Commission