Pattern of Hormone Receptor Status in Breast Cancer Patients in the Rural Population Tamilnadu - A Descriptive Study

Breast cancer is most frequently diagnosed cancer and most frequent cause for cancer-related deaths in women worldwide. Globally, breast cancer accounted 2.08 million out of 18.08 million new cancer cases (incidence rate of 11.6%) and 626,679 out of 9.55 million cancer-related deaths (6.6% of all cancer related deaths). In India, breast cancer has surpassed cancers of cervix and oral cavity to be most common cancer and leading cause of cancer deaths. Modern classification of breast cancer is based on immunohistochemistry, histopathologic features, and molecular characterisation. Two most frequent histologic subtypes of invasive breast cancer are invasive ductal carcinoma and invasive lobular carcinoma (80% to 85% and 10% to 15% of all cases, respectively). Other subtypes compose remaining, 1% of invasive breast cancers. IHC characterisation of breast cancer is important for deciding treatment of breast cancer and for predicting prognosis. IHC characterisation depends on expression of biomarkers such as oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2(HER2). Aims and Objectives: To analyse the Pattern of Hormonal Receptors status (ER, PR, Her2Neu, Ki67) and its correlation with age and with pathological prognostic factors in carcinoma breast. Material and Methods: This is a Descriptive study with a proper diagnostic accuracy done among 105 cancer breast patients presented to Government Villupuram Medical College and Hospital, Villupuram, Tamilnadu. Results: In the present study,38% were in the age group of 41 to 50. Mean age is 48.76 and standard deviation is 4.56. 82% were Invasive Ductal Carcinoma,52% were stage 1 cancer,41% were ER-/PR- 71% were her2neu negative,62%were right side breast cancer ,43% were 4 nodes positive,46% were ki67 20%, 52% were given chemotherapy before surgery ,57% were not given chemotherapy after surgery.