Declining Prevalence of Human Papillomavirus Co‐Infections Among Young Japanese Women With Cervical Cancer and Its Precursors

Co-infections with human papillomavirus (HPV) of multiple genotypes mainly occur due to increased sexual activity. To address the prevalence and trend of HPV co-infections in Japan, HPV-type-specific data from Japanese women (n = 8128) aged < 40 years and newly diagnosed with cervical abnormalities at 24 hospitals between 2012 and 2023 were analyzed. These included cervical intraepithelial neoplasia grade 1/2 (CIN1/2, n = 2745), CIN3/adenocarcinoma in situ (AIS) (n = 3953), and invasive cervical cancer (ICC, n = 1430). For women enrolled in this study since 2019, information on sexual behaviors was collected via a self-administered questionnaire. Time-trend analyses by disease category showed significant declines in the prevalence of multiple HPV infections in CIN1/2 (49.1%-38.3%, p<sub>trend</sub> = 0.0004), CIN3/AIS (44.7%-31.5%, p<sub>trend</sub> = 0.0002), and ICC (26.7%-10.5%, p<sub>trend</sub> < 0.0001) during the last decade. When these data were analyzed separately for women aged 20-29 and 30-39 years, similar declining trends were observed in each disease category. Using data from 2111 women for whom information on sexual history was available, the number of sexual partners was strongly associated with increased multiple HPV infections (p < 0.0001). In conclusion, the declining prevalence of HPV co-infections in cervical cancer and its precursors may reflect a decrease in sexual activity among Japanese women of reproductive age.

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Publication Details

Journal
Journal of Medical Virology
Published
2024-12-01
DOI
https://doi.org/10.1002/jmv.70096
Primary Topic
Cervical Cancer and HPV Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Declining Prevalence of Human Papillomavirus Co‐Infections Among Young Japanese Women With Cervical Cancer and Its Precursors

Iwao Kukimoto, Nobuo Yaegashi, Yasuyuki Hirashima, Yuri Tenjimbayashi et al.
Journal of Medical Virology
Cervical Cancer and HPV Research
article

Declining Prevalence of Human Papillomavirus Co‐Infections Among Young Japanese Women With Cervical Cancer and Its Precursors

Iwao Kukimoto, Nobuo Yaegashi, Yasuyuki Hirashima, Yuri Tenjimbayashi, Mamiko Onuki, Mayuko Goda, Hiroyuki Kanao, Hiroyuki Yoshida, Takeshi Motohara, Hiroyuki Yoshikawa, Ai Nio, Tsuyoshi Hisa, Tomoya Matsui, Shogo Shigeta, Kazuto Tasaki, Haruya Saji, Yuji Takei, Hiroko Matsumiya, Fumiaki Takahashi, Akihiko Sekizawa, Eri Yoshiizumi, Hideaki Yahata, Wataru Kudaka, Kyoko Hamasaki, Mayuyo Mori‐Uchino, Keiichiro Nakamura, Koji Matsumoto, Junzo Hamanishi, Hidekatsu Nakai, Mitsuya Ishikawa, Takanori Yokoyama
article en

Abstract

Co-infections with human papillomavirus (HPV) of multiple genotypes mainly occur due to increased sexual activity. To address the prevalence and trend of HPV co-infections in Japan, HPV-type-specific data from Japanese women (n = 8128) aged < 40 years and newly diagnosed with cervical abnormalities at 24 hospitals between 2012 and 2023 were analyzed. These included cervical intraepithelial neoplasia grade 1/2 (CIN1/2, n = 2745), CIN3/adenocarcinoma in situ (AIS) (n = 3953), and invasive cervical cancer (ICC, n = 1430). For women enrolled in this study since 2019, information on sexual behaviors was collected via a self-administered questionnaire. Time-trend analyses by disease category showed significant declines in the prevalence of multiple HPV infections in CIN1/2 (49.1%-38.3%, p<sub>trend</sub> = 0.0004), CIN3/AIS (44.7%-31.5%, p<sub>trend</sub> = 0.0002), and ICC (26.7%-10.5%, p<sub>trend</sub> < 0.0001) during the last decade. When these data were analyzed separately for women aged 20-29 and 30-39 years, similar declining trends were observed in each disease category. Using data from 2111 women for whom information on sexual history was available, the number of sexual partners was strongly associated with increased multiple HPV infections (p < 0.0001). In conclusion, the declining prevalence of HPV co-infections in cervical cancer and its precursors may reflect a decrease in sexual activity among Japanese women of reproductive age.

Journal of Medical VirologyVol. 96(12)
Kurume University (JP), SHOWA Medical University (JP), Kyushu University (JP), University of Tsukuba (JP), Jichi Medical University (JP), Okayama University (JP), Iwate Medical University (JP), Tohoku University (JP), Keio University (JP), Hokkaido University (JP), Kyoto University (JP), Kanagawa Prefectural Hospital Organization (JP), University of the Ryukyus (JP), National Institute of Infectious Diseases (JP), Shizuoka Cancer Center (JP), National Hospital Organization Kyushu Cancer Center (JP), Saitama Cancer Center (JP), The Cancer Institute Hospital (JP), Shikoku Cancer Center (JP), Osaka International Cancer Institute (JP), Tokyo National Hospital (JP), Hyogo Prefectural Cancer Center (JP), Kanagawa Cancer Center, The University of Tokyo (JP), Saitama Medical University (JP), Kindai University (JP), Kumamoto University (JP)
Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science
Gender equality, Good health and well-being
Openalex Percentile: Top 66%
Cervical Cancer and HPV Research
DOIOpen Access PDFOpenAlex
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