Advances in Metabolomics based on Mass Spectrometry

Metabonomics, as systems biology's most downstream "omics, is the integrity of the system function change important branch discipline of life. Metabonomics is a research field that focuses on complex biological systems, and there are numerous types of common biological samples, such as biological fluids (urine, saliva, serum, plasma, bile, cerebrospinal fluid, amniotic fluid, tears, pancreatic juice, and intestinal juice, etc.), animal or human tissue (tumor, liver, brain, adipose tissue, etc.), and cells. Metabonomics typically employs two categories of commonly used research methods: mass spectrometry and nuclear magnetic resonance. This paper presents a comprehensive review of the research progress in the field of metabonomics within the medical field. The focus is on disease diagnosis, drug research and development, as well as their relationship to nutrition, toxicology, sports medicine, and other related areas. This review is based on an analysis of mass spectrometry. Despite the significant progress made in science, technology, and research, metabolics research still faces a multitude of challenges and opportunities. The ongoing development and innovation of mass spectrometry technology are crucial for the field's advancement. While mass spectrometry has played a pivotal role in metabolomics research, there is a pressing need to enhance its performance in order to improve sensitivity, resolution, and analysis throughput.