Temperature-Dependent Diastereodivergent [4 + 3] Annulation: Synthesis of Ferrocene-Fused Azepines via Rh(III) Catalysis
Herein, we disclose the first temperature-dependent diastereodivergent [4 + 3] annulation of ferrocene-<i>p</i>-tosylamides <i>via</i> C-H activation with allenes by a Rh catalyst. At room temperature, Rh-catalyzed [4 + 3] annulation selectively offered a kinetically controlled diastereomer [>20:1 diastereomeric ratio (dr)], whereas at 60 °C, a thermodynamically controlled diastereomer was obtained exclusively with >20:1 dr.
Authors
- Devendra Parganiha (ORCID: https://orcid.org/0000-0001-8826-7540)
- Raviraj Ananda Thorat (ORCID: https://orcid.org/0000-0001-6106-556X)
- Saket Jain (ORCID: https://orcid.org/0000-0002-3350-2731)
- Sangit Kumar (ORCID: https://orcid.org/0000-0003-0658-8709)
- Raushan Kumar Jha (ORCID: https://orcid.org/0000-0002-2143-0937)
- Vipin Choudhary (ORCID: https://orcid.org/0009-0003-7862-5334)
- Batul Shakir (ORCID: https://orcid.org/0000-0002-4736-1095)
- Komal Rohilla (ORCID: https://orcid.org/0009-0001-5101-6788)
Institutions
- Indian Institute of Science Education and Research, Bhopal (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1021/acs.orglett.4c03954
- Citations
- 7
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Indian Institute of Science Education and Research Bhopal
- Science and Engineering Research Board
- University Grants Commission - South Eastern Regional Office