Upregulation of HPV16E1 and E7 expression and FOXO3a mRNA downregulation in high-grade cervical neoplasia
HPV16 early mRNA levels, including E1 and E7, increase during cancer progression, and downregulation of FOXO3a mRNA is a characteristic of cervical cancer cells and HSIL/SCC. Additionally, HPV16E4 mRNA expression was consistently detected in all LSIL samples, suggesting the presence of active viral replication. These findings might lead to further investigation into the interplay between HPV gene expression and host cell factors for targeted therapeutic strategies in cervical cancer management.
Authors
- Arkom Chaiwongkot (ORCID: https://orcid.org/0000-0003-1070-6747)
- Asep Gunawan (ORCID: https://orcid.org/0000-0003-0468-2443)
- Pattarasinee Bhattarakosol (ORCID: https://orcid.org/0000-0002-9938-028X)
- Thanayod Sasivimolrattana (ORCID: https://orcid.org/0000-0002-7770-1097)
- Parvapan Bhattarakosol (ORCID: https://orcid.org/0000-0002-9750-9609)
- Warattaya Wattanathavorn (ORCID: https://orcid.org/0009-0000-6807-299X)
- Chavis Pholpong (ORCID: https://orcid.org/0009-0006-4106-351X)
Institutions
- Chulalongkorn University (TH)
- Mahidol University (TH)
- Indonesia International Institute for Life Sciences (ID)
Publication Details
- Journal
- PeerJ
- Published
- 2024-12-06
- DOI
- https://doi.org/10.7717/peerj.18601
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chulalongkorn University
- Faculty of Medicine, Chulalongkorn University