P-80 RECURRENCE OF PRIMARY SCLEROSING CHOLANGITIS AFTER LIVER TRANSPLANTATION: RESULTS FROM THE BRAZILIAN CHOLESTASIS CONSORTIUM
Yes, This work was supported by Brazilian Society of Hepatology and Instituto Brasileiro do Fígado - IBRAFIG. Previous studies have identified risk factors associated with recurrent primary sclerosing cholangitis (rPSC) after liver transplantation (LT) in Caucasians. There is paucity of data regarding rPSC in multiethnic Latin patients. Objectives: To investigate rPSC frequency and its associated risk factors in a highly admixed population from Brazil. The Brazilian Cholestasis Study Group database was retrospectively reviewed for including primary sclerosing cholangitis (PSC) patients who underwent LT. Primary outcome was rPSC. A total of 96 patients were included, 60% males, mean age 32 ± 13 years. After a follow-up of 90 months (interquartile range 39-154), rPSC occurred in 29 (30%) of the participants. There were no statistically significant associations between rPSC and age, gender, concurrent or de novo inflammatory bowel disease, MELD score at the time of LT or allograft rejection. The only factor associated with an increased risk of disease recurrence was time after LT. In Brazilian PSC patients who underwent LT, one-third had rPSC. Longer time after LT was associated with rPSC diagnosis.
Authors
- Mateus Jorge Nardelli (ORCID: https://orcid.org/0000-0001-7199-9980)
- Eduardo Luiz Rachid Cançado (ORCID: https://orcid.org/0000-0002-9309-1524)
- Cláudia Alexandra Pontes Ivantes (ORCID: https://orcid.org/0000-0001-5422-557X)
- Guilherme Eduardo Gonçalves Felga (ORCID: https://orcid.org/0000-0002-0676-4867)
- Luciana Costa Faria (ORCID: https://orcid.org/0000-0002-0226-3491)
- Luísa Leite Barros (ORCID: https://orcid.org/0000-0002-7782-2825)
- Elodie Bonfim Hyppolito
- Adrielly de Souza Martins
- Maria Lúcia Gomes Ferraz (ORCID: https://orcid.org/0000-0001-8992-8494)
- Geisa Perez Medina Gomide (ORCID: https://orcid.org/0000-0002-6657-5515)
- Cláudia Alves Couto (ORCID: https://orcid.org/0000-0002-9776-4757)
- Liliana Sampaio Costa Mendes (ORCID: https://orcid.org/0000-0003-2447-8845)
- Cristiane Alves Villela‐Nogueira (ORCID: https://orcid.org/0000-0003-1355-2368)
- Vivian Rotman (ORCID: https://orcid.org/0000-0003-0522-396X)
- Débora Raquel Benedita Terrabuio (ORCID: https://orcid.org/0000-0003-4072-1761)
- Izabelle Venturini Signorelli
- Guilherme Grossi Lopes Cançado (ORCID: https://orcid.org/0000-0002-7824-2152)
- Marlone Cunha‐Silva (ORCID: https://orcid.org/0000-0002-4424-6606)
- Rodrigo Rocco
- Valéria Ferreira de Almeida e Borges (ORCID: https://orcid.org/0000-0001-8663-2700)
- Liana Codés (ORCID: https://orcid.org/0000-0001-5178-8705)
- Diogo Delgado Dotta (ORCID: https://orcid.org/0000-0002-3790-5079)
- Maria Chiara Chindamo (ORCID: https://orcid.org/0000-0002-5817-9221)
- M. B. de Oliveira
- Paulo Lisboa Bittencourt
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal do Rio de Janeiro (BR)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Hospital Israelita Albert Einstein (BR)
- Universidade Brasil (BR)
- Real Hospital Português (BR)
- Complexo Hospitalar Universitário Professor Edgard Santos (BR)
- Universidade Federal do Triângulo Mineiro (BR)
- Hospital Universitário Walter Cantídio (BR)
- Prefeitura Municipal de Campos dos Goytacazes (BR)
- Hospital das Clínicas da Universidade Federal de Minas Gerais (BR)
- Hospital Universitário Clementino Fraga Filho (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.aohep.2024.101694
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00