Sympathetic Response to 1-Leg Cycling Exercise Predicts Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction
In contrast to CMCs, patients with HFpEF exhibit augmented MSNA at rest and during exercise. The magnitude of such paradoxical sympathoexcitation during dynamic cycling relates inversely to V̇O<sub>2peak</sub>, consistent with a neurogenic, vasoconstrictor limit on exercise capacity in HFpEF.
Authors
- Massimo Nardone (ORCID: https://orcid.org/0000-0002-1990-6481)
- David Z.I. Cherney (ORCID: https://orcid.org/0000-0003-4164-0429)
- Susanna Mak (ORCID: https://orcid.org/0000-0003-2193-602X)
- Evan Keys (ORCID: https://orcid.org/0000-0001-6693-3258)
- Tomoyuki Tobushi (ORCID: https://orcid.org/0000-0001-5759-2252)
- Mark B. Badrov (ORCID: https://orcid.org/0000-0001-7809-0729)
- Catherine F. Notarius (ORCID: https://orcid.org/0000-0001-7911-2950)
- John S. Floras (ORCID: https://orcid.org/0000-0002-1899-5371)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- York University (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Sinai Health System (CA)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1161/circheartfailure.124.011962
- Citations
- 4
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 2.86