The impact of diabetes on spermatogenesis

Diabetes mellitus, a chronic metabolic disease characterized by persistent hyperglycemia, has been shown to have a significant impact on several body systems, including the male reproductive system, spermatogenesis, the process of sperm formation and development in the testes, can be adversely affected by the direct and indirect effects of diabetes, the main mechanisms involving oxidative damage, hormonal alterations, mitochondrial dysfunction and endoplasmic stress, The main mechanisms involve oxidative damage, hormonal alterations, mitochondrial dysfunction and endoplasmic stress, which can lead to a reduction in the quality and quantity of spermatozoa, as well as in their motility and morphology. In addition, diabetes can induce chronic inflammation and affect the integrity of the blood-testicular barrier, which alters the microenvironment necessary for healthy spermatogenesis, in the present communication we describe the theoretical aspects of the effects of diabetes on seminal fluid with emphasis on spermatogenesis as well as its impact on male fertility.