Geographical variation in lung function: Results from the multicentric cross-sectional BOLD study

Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV<sub>1</sub>/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, had never smoked and reported no respiratory symptoms or diagnoses. To identify regions with similar FVC, we conducted a principal component analysis (PCA) on FVC with age, age<sup>2</sup> and height<sup>2</sup>, separately for men and women. We regressed FVC against age, age<sup>2</sup> and height<sup>2</sup>, and FEV<sub>1</sub>/FVC against age and height<sup>2</sup>, for each sex and site, stratified by region. Mean age was 54 years (both sexes), and mean height was 1.69 m (men) and 1.61 m (women). The PCA suggested four regions: 1) Europe and richer countries; 2) the Near East; 3) Africa; and 4) the Far East. For the FVC, there was little variation in the coefficients for age, or age<sup>2</sup>, but considerable variation in the constant (men: 2.97 L in the Far East to 4.08 L in Europe; women: 2.44 L in the Far East to 3.24 L in Europe) and the coefficient for height<sup>2</sup>. Regional differences in the constant and coefficients for FEV<sub>1</sub>/FVC were minimal (<1%). The relation of FVC with age, sex and height varies across and within regions. The same is not true for the FEV<sub>1</sub>/FVC ratio.

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Journal
Pulmonology
Published
2024-12-06
DOI
https://doi.org/10.1080/25310429.2024.2430491
Citations
2
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
Field-Weighted Citation Impact
0.84

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article

Geographical variation in lung function: Results from the multicentric cross-sectional BOLD study

Sanjay Juvekar, James E. Potts, Padukudru Anand Mahesh, Frits M.E. Franssen et al.
2 citations
Pulmonology
Chronic Obstructive Pulmonary Disease (COPD) Research
0.84
article

Geographical variation in lung function: Results from the multicentric cross-sectional BOLD study

Sanjay Juvekar, James E. Potts, Padukudru Anand Mahesh, Frits M.E. Franssen, William M. Vollmer, Abdul Rashid, Daniel Obaseki, Stefanni Nonna M Paraguas, Peter Burney, Christer Janson, Li Cher Loh, André F.S. Amaral, Hermínia Brites Dias, Rana Ahmed, Mohammed Al Ghobain, Emiel F.�M. Wouters, Fátima Rodrigues, Ben Knox‐Brown, Asma Elsony, Terence Seemungal, Hamid Hacene Cherkaski, Cristina Bárbara, João Cardoso, David M. Mannino, Gregory E. Erhabor, Imed Harrabi, Asaad Ahmed Nafees, Parvaiz A Koul, Rune Nielsen, Thorarinn Gislason, M. El Biaze, Eric Bateman, Kevin Mortimer, Dhiraj Agarwal, A. Sonia Buist
article en
2 citations

Abstract

Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV<sub>1</sub>/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, had never smoked and reported no respiratory symptoms or diagnoses. To identify regions with similar FVC, we conducted a principal component analysis (PCA) on FVC with age, age<sup>2</sup> and height<sup>2</sup>, separately for men and women. We regressed FVC against age, age<sup>2</sup> and height<sup>2</sup>, and FEV<sub>1</sub>/FVC against age and height<sup>2</sup>, for each sex and site, stratified by region. Mean age was 54 years (both sexes), and mean height was 1.69 m (men) and 1.61 m (women). The PCA suggested four regions: 1) Europe and richer countries; 2) the Near East; 3) Africa; and 4) the Far East. For the FVC, there was little variation in the coefficients for age, or age<sup>2</sup>, but considerable variation in the constant (men: 2.97 L in the Far East to 4.08 L in Europe; women: 2.44 L in the Far East to 3.24 L in Europe) and the coefficient for height<sup>2</sup>. Regional differences in the constant and coefficients for FEV<sub>1</sub>/FVC were minimal (<1%). The relation of FVC with age, sex and height varies across and within regions. The same is not true for the FEV<sub>1</sub>/FVC ratio.

PulmonologyVol. 31(1)
Badji Mokhtar-Annaba University (DZ), Sigmund Freud Privatuniversität Wien (AT), Aga Khan University (PK), RCSI & UCD Malaysia Campus (MY), Uppsala University (SE), American College of Chest Physicians (US), University of Lisbon (PT), University of British Columbia (CA), Royal College of Surgeons in Ireland (IE), University of Kentucky (US), University of Liverpool (GB), University of Cape Town (ZA), University of Iceland (IS), Oregon Health & Science University (US), King Saud bin Abdulaziz University for Health Sciences (SA), Universidade Politécnica de Lisboa (PT), Sher-i-Kashmir Institute of Medical Sciences (IN), University of Cambridge (GB), Aintree University Hospitals NHS Foundation Trust (GB), Maastricht University Medical Centre (NL), Haukeland University Hospital (NO), University of the West Indies (TT), Dr. D. Y. Patil Medical College, Hospital and Research Centre (IN), Sigmund Freud Privatuniversität - Standort Mailand (IT), Departamento de Epidemiología (GT), Unidade Local de Saúde de São José (PT), King Abdullah International Medical Research Center (SA), National University Hospital of Iceland (IS), NIHR Imperial Biomedical Research Centre (GB), Centro Hospitalar Lisboa Norte (PT), Kaiser Permanente Center for Health Research (US), COPD Foundation (US), Obafemi Awolowo University Teaching Hospitals Complex (NG), Philippine Heart Center (PH), University of Bergen (NO), Imperial College London (GB), Sidi Mohamed Ben Abdellah University (MA), Universidade Nova de Lisboa (PT), University of Sousse (TN), JSS Medical College and Hospital (IN)
Pfizer, AstraZeneca, GlaxoSmithKline, Air Liquide, Guangzhou Medical University, Wellcome Trust, Chest Research Foundation, International Development Research Centre, Pfizer Australia, GlaxoSmithKline Australia, South African Medical Research Council, South African Thoracic Society, Landspítali Háskólasjúkrahús, Medizinischen Hochschule Hannover, Paracelsus Medizinische Privatuniversität, AstraZeneca Pharma Poland, Medical Research Council
Openalex Percentile: Top 22%
Chronic Obstructive Pulmonary Disease (COPD) Research
0.84
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