Regenerative Potential Nanomedicine of Adipocyte Stem Cell-Derived Exosomes in Senescent Skin Tissue
HADSCs-CM significantly alleviated signs of skin senescence, including reduced dermal thickness, decreased VEGF expression, and enhanced collagen production. Exosomes, identified in the HADSCs-CM, are the functional component of these regenerative effects. This study highlights that the exosomal nanomedicine found in HADSCs-CM could regenerate skin, boost collagen production, improve fibroblast cell viability, and contain functional exosomes.
Authors
- Jinghua Sun (ORCID: https://orcid.org/0000-0002-4217-7854)
- Yong Diao (ORCID: https://orcid.org/0000-0002-0633-1906)
- Jia-Shen Li
- Chia‐Hung Kuo (ORCID: https://orcid.org/0000-0003-3445-5663)
- Syafiqah Saidin (ORCID: https://orcid.org/0000-0002-5114-3453)
- J. Cheah
- Huimin Wang (ORCID: https://orcid.org/0000-0002-4692-4917)
- Ling Li (ORCID: https://orcid.org/0000-0001-7568-939X)
- Anna Li (ORCID: https://orcid.org/0000-0002-4180-6153)
- Ruyu Bai
Institutions
- Hebei Medical University (CN)
- Huaqiao University (CN)
- Kaohsiung Medical University (TW)
- National Chung Hsing University (TW)
- China Medical University (TW)
- Second Hospital of Hebei Medical University (CN)
- First Hospital of Shijiazhuang (CN)
- National Kaohsiung Marine University (TW)
- National Kaohsiung University of Science and Technology (TW)
- University of Technology Malaysia (MY)
- National Cheng Kung University (TW)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/ijn.s470225
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.47