Locus coeruleus tau is linked to successive cortical tau accumulation
Tau burden in the LC was significantly associated with cortical tau accumulation. Tau burden in SN or PPN showed no association with cortical tau accumulation. LC tau burden was serially associated with Braak stages. The tau-LC and cortical tau relationship was significant only in the Aβ-positive group. Cortical amyloid's impact on memory worsens with higher tau accumulation in the LC.
Authors
- Yoon Young Chang (ORCID: https://orcid.org/0009-0006-0279-1880)
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Musung Keum (ORCID: https://orcid.org/0000-0002-0855-8637)
- Hye‐Jin Ahn (ORCID: https://orcid.org/0000-0002-0085-9566)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Joon Hyung Jung (ORCID: https://orcid.org/0000-0003-1669-6113)
- Koung Mi Kang (ORCID: https://orcid.org/0000-0001-9643-2008)
- Yun‐Sang Lee
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Yoon‐Keun Kim (ORCID: https://orcid.org/0000-0001-7610-7654)
- Dong Young Lee (ORCID: https://orcid.org/0009-0006-0924-6607)
Institutions
- Seoul National University (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Inje University Sanggye Paik Hospital (KR)
- Indiana University Bloomington (US)
- Chungbuk National University Hospital (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1002/alz.14426
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- Seoul National University
- National Institutes of Health