Association of ten VEGF family genes with Alzheimer's disease endophenotypes at single cell resolution
The prefrontal cortical expression of FLT1 and FLT4 was associated with worse cross-sectional global cognitive function, longitudinal cognitive trajectories, and more Alzheimer's disease (AD) neuropathology. The associations between FLT1 or FLT4 and AD endophenotypes appear to be driven by endothelial and microglial cells. VEGFB expression seems to have opposing effects on the Aβ burden in AD depending on cell types, highlighting its potential protective role in neurons.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Julia B. Libby (ORCID: https://orcid.org/0000-0002-6498-3662)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Yiyang Wu (ORCID: https://orcid.org/0000-0002-9231-7093)
Institutions
- Rush University Medical Center (US)
- Columbia University Irving Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1002/alz.14419
- Citations
- 12
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.97
Funders
- National Institute on Aging