The POINTER Imaging baseline cohort: Associations between multimodal neuroimaging biomarkers, cardiovascular health, and cognition
·The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) cohort is enriched for cardiovascular disease (CVD) and poor lifestyle ·POINTER Imaging collected multimodal neuroimaging data in this unique, at-risk cohort ·Amyloid burden was related to age, apolipoprotein E (APOE) ε4 carriage, and measures of disease progression ·Associations between amyloid and tau, and tau and cognition, were relatively weak ·CVD risk and tau pathology were independently related to memory.
Authors
- Neelum T. Aggarwal (ORCID: https://orcid.org/0000-0002-4341-8023)
- Laura Lovato
- Heather M. Snyder (ORCID: https://orcid.org/0000-0002-7665-7696)
- Stephen Salloway (ORCID: https://orcid.org/0000-0002-2631-0942)
- Darren R. Gitelman (ORCID: https://orcid.org/0000-0001-6057-5605)
- Maryjo Cleveland
- Danielle Harvey (ORCID: https://orcid.org/0000-0002-5367-0951)
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Valory Pavlik (ORCID: https://orcid.org/0000-0003-4376-3756)
- Laura D. Baker (ORCID: https://orcid.org/0000-0002-6217-7384)
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Mark A. Espeland (ORCID: https://orcid.org/0000-0002-3711-1949)
- Samuel N. Lockhart (ORCID: https://orcid.org/0000-0002-0893-5420)
- Charles DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
- Melissa Yu
- Theresa M. Harrison (ORCID: https://orcid.org/0000-0002-2036-3496)
- Robert A. Koeppe (ORCID: https://orcid.org/0000-0002-9514-5311)
- Christy Tangney (ORCID: https://orcid.org/0000-0002-2431-9687)
- Youngkyoo Jung (ORCID: https://orcid.org/0000-0002-7236-8897)
- Rachel A. Whitmer (ORCID: https://orcid.org/0009-0006-9511-6138)
- Tyler J. Ward (ORCID: https://orcid.org/0000-0002-4681-8137)
- William J. Jagust
- Sarah Tomaszewski Farias (ORCID: https://orcid.org/0009-0009-8969-3387)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- Susan M. Landau
- Jacinda Taggett
Institutions
- Alzheimer's Association (US)
- Rush University Medical Center (US)
- Houston Methodist (US)
- Mayo Clinic (US)
- Lawrence Berkeley National Laboratory (US)
- Baylor College of Medicine (US)
- Cornell University (US)
- Brown University (US)
- University of Michigan (US)
- Advocate Health Care (US)
- Wake Forest University (US)
- University of California, Davis (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1002/alz.14399
- Citations
- 10
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 3.86
Funders
- Alzheimer's Association
- National Institute on Aging