Clinical value of novel blood‐based tau biomarkers in Creutzfeldt–Jakob disease
The increase of plasma BD-tau levels parallels that of CSF t-tau in CJD. CSF p-tau217 levels are significantly increased in CJD, reflecting a prion-specific secondary tauopathy. Plasma p-tau217 shows a distinct profile than CSF p-tau217 in CJD. Plasma BD-tau/p-tau217 ratio is as accurate as CSF 14-3-3 in distinguishing CJD from np-RPDs, including AD. BD-tau represents a valuable blood-based biomarker for CJD prognostication.
Authors
- Giuseppe Mario Bentivenga
- Simone Baiardi (ORCID: https://orcid.org/0000-0002-7702-7856)
- Piero Parchi (ORCID: https://orcid.org/0000-0002-9444-9524)
- Bjørn‐Eivind Kirsebom (ORCID: https://orcid.org/0000-0002-1413-9578)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Angela Mammana (ORCID: https://orcid.org/0000-0002-3306-8365)
- Sabina Capellari (ORCID: https://orcid.org/0000-0003-1631-1439)
- Kaj Blennow
- Andrea Mastrangelo (ORCID: https://orcid.org/0000-0003-1578-8112)
- Tormod Fladby
- Henrik Zetterberg
Institutions
- University of Science and Technology of China (CN)
- University Hospital of North Norway (NO)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University College London (GB)
- UiT The Arctic University of Norway (NO)
- University of Gothenburg (SE)
- University of Bologna (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1002/alz.14422
- Citations
- 19
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 4.44
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Partnership on Metrology
- National Institute for Health and Care Research
- University College London
- European Commission
- Ministero della Salute
- Hjärnfonden
- Vetenskapsrådet
- Norges Forskningsråd
- UK Dementia Research Institute
- Fondation pour la Recherche sur Alzheimer
- HORIZON EUROPE Framework Programme