Probing the interaction of cisplatin with calmodulin and its effect upon binding to myosin light-chain kinase
Cisplatin inhibits the interaction between CaM and MLCK, leading to the mobilization of bound Ca 2+ ions and disruption of CaM functions. The findings provide mechanistic insights into the neurotoxicity caused by the drug.
Authors
- Hongze Hu
- Fabio Arnesano (ORCID: https://orcid.org/0000-0002-8399-0964)
- Giovanni Natile (ORCID: https://orcid.org/0000-0002-1790-6365)
- Yangzhong Liu (ORCID: https://orcid.org/0000-0003-2891-7964)
- Liqin Tang (ORCID: https://orcid.org/0000-0001-8029-7091)
- S. Wang
- Yu Wang (ORCID: https://orcid.org/0000-0002-9071-0238)
- Kaiming Cao (ORCID: https://orcid.org/0000-0002-3737-188X)
- Aizong Shen (ORCID: https://orcid.org/0000-0002-8863-9882)
- Siming Yuan
Institutions
- University of Science and Technology of China (CN)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Inorganic Chemistry Frontiers
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1039/d4qi02844a
- Citations
- 1
- Primary Topic
- Alkaline Phosphatase Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.36