Influence of medical conditions on the diagnostic accuracy of plasma p‐tau217 and p‐tau217/Aβ42
Plasma Aβ42/40, p-tau181, p-tau217, and GFAP but not NfL showed significant associations with brain Aβ. BBMs were more strongly associated with the level of brain Aβ in those without diabetes and cardiovascular conditions. P-tau217/Aβ42 showed the best performance (AUC = 0.91) in discriminating Aβ presence with an optimal cut-off of >1.2, followed by p-tau217 at >0.46 pg/mL, with performance slightly improving when excluding participants with cardiovascular conditions.
Authors
- Bradley P. Sutton (ORCID: https://orcid.org/0000-0002-8443-0408)
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- Xuemei Zeng (ORCID: https://orcid.org/0000-0003-4885-4788)
- Arthur Kramer (ORCID: https://orcid.org/0000-0002-1991-5046)
- Eric D. Vidoni (ORCID: https://orcid.org/0000-0001-5181-7131)
- Edward McAuley (ORCID: https://orcid.org/0000-0002-4574-3292)
- Audrey M. Collins
- Lauren E. Oberlin (ORCID: https://orcid.org/0000-0001-9553-8070)
- Marcos Olvera‐Rojas (ORCID: https://orcid.org/0000-0001-7922-1647)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Jermon A. Drake (ORCID: https://orcid.org/0000-0001-7560-1861)
- Anna L. Marsland (ORCID: https://orcid.org/0000-0001-8951-7513)
- John M. Jakicic (ORCID: https://orcid.org/0000-0001-6800-9368)
- Kelsey R. Sewell (ORCID: https://orcid.org/0000-0002-3859-5017)
- Anuradha Sehrawat (ORCID: https://orcid.org/0000-0002-7243-5447)
- Charles H. Hillman (ORCID: https://orcid.org/0000-0002-3722-5612)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- M. Ilyas Kamboh (ORCID: https://orcid.org/0000-0002-3453-1438)
- Haiqing Huang (ORCID: https://orcid.org/0000-0002-8932-7995)
- Chaeryon Kang (ORCID: https://orcid.org/0000-0001-9442-8515)
- Tara K Lafferty
- Yijun Chen (ORCID: https://orcid.org/0000-0002-4920-152X)
- Lu Wan
Institutions
- Northeastern University (US)
- University of Kansas (US)
- University of Illinois Urbana-Champaign (US)
- University of Pittsburgh (US)
- Universidad de Granada (ES)
- Murdoch University (AU)
- Cornell University (US)
- Chevron (United States) (US)
- University of Kansas Medical Center (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1002/alz.14430
- Citations
- 21
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.10
Funders
- University of Kansas
- University of Pittsburgh
- Ministerio de Ciencia, Innovación y Universidades
- Universidad de Granada
- National Institutes of Health
- University of Kansas Medical Center