Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas
Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians.
Authors
- Linda Feeley (ORCID: https://orcid.org/0000-0002-7521-8253)
- Killian Nugent
- Philip Bredin (ORCID: https://orcid.org/0000-0003-2560-8699)
- Séamus O’Reilly (ORCID: https://orcid.org/0000-0002-2887-7336)
- Julie McCarthy (ORCID: https://orcid.org/0000-0002-6370-5951)
- Sebastian McWilliams
- Orla O’Mahony (ORCID: https://orcid.org/0009-0000-5914-0030)
- David O’Reilly (ORCID: https://orcid.org/0000-0001-8491-8916)
- Patrick Sheahan (ORCID: https://orcid.org/0000-0002-9153-8951)
- Emer Lynch (ORCID: https://orcid.org/0009-0006-2510-6110)
- Deirdre O’Hanlon
- Simon Barry (ORCID: https://orcid.org/0009-0007-5042-1558)
Institutions
- University College Cork (IE)
- Beaumont Hospital (IE)
- Cork University Hospital (IE)
- South Infirmary Victoria University Hospital (IE)
Publication Details
- Journal
- Onco
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3390/onco4040030
- Citations
- 1
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.36