Genomic insights on cgMLST markers, drug resistance, and urease cluster of <i>Proteus mirabilis</i> strains

The bacterium <i>Proteus mirabilis</i> is a common pathogenic bacterium that is known to cause a variety of human infections. The drug-resistant genes carried by <i>P. mirabilis</i> present a significant challenge to clinical treatment, particularly in regard to the organism's notable resistance to commonly used beta-lactam and quinolone drugs. Furthermore, the prevalence of the urease gene cluster of <i>P. mirabilis</i> at the urease gene level may be associated with the formation of kidney stones. The objective of the study is to analyze the bacterium's drug resistance, urease gene clusters, and gene distribution in genomes in order to facilitate the development of antimicrobial drugs and improve the treatment and control of <i>P. mirabilis</i> infections.