Calibration free approaches for rapid polymorph discrimination <i>via</i> low frequency (THz) Raman spectroscopy
Application of multivariate curve resolution to non-invasive Raman spectra has been investigated for rapid on-line analysis of crystallisation processes and high-throughput screening. Exploring quantification of mefenamic acid solid forms (form I, form II, and dimethylformamide solvate) from the Raman spectra indicated excellent agreement with off-line X-ray analysis.
Authors
- Martin R. Ward (ORCID: https://orcid.org/0000-0003-0013-5004)
- Catriona McFarlan (ORCID: https://orcid.org/0000-0003-1571-7533)
- John Andrews (ORCID: https://orcid.org/0000-0002-2316-3959)
- Magdalene W. S. Chong
- Alison Nordon (ORCID: https://orcid.org/0000-0001-6553-8993)
- Andrew J. Parrott
- Iain D. H. Oswald (ORCID: https://orcid.org/0000-0003-4339-9392)
- Paul Dallin
Institutions
- Engineering and Physical Sciences Research Council (GB)
- University of Strathclyde (GB)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1039/d4cc05591h
- Citations
- 1
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.66
Funders
- Department for Business, Energy and Industrial Strategy, UK Government
- National Nuclear Laboratory
- Engineering and Physical Sciences Research Council