Modulatory effects of CNNM4 on protein-l-isoaspartyl-O-methyltransferase repair function during alcohol-induced hepatic damage
These findings shed light on the dysregulation of Mg 2+ homeostasis in ALD, providing a promising therapeutic approach targeting CNNM4. N -acetylgalactosamine si Cnnm4 therapy boosts the repair processes of ethanol-damaged proteins through the upregulation of PCMT1 activity.
Authors
- Elisa Pose (ORCID: https://orcid.org/0000-0002-0224-7686)
- Rubén Rodríguez Agudo
- Paula Iruzubieta (ORCID: https://orcid.org/0000-0001-9476-1801)
- Jordi Gratacós‐Ginès (ORCID: https://orcid.org/0000-0003-1181-7238)
- Matías A. Ávila (ORCID: https://orcid.org/0000-0001-6570-3557)
- Unai Galicia García (ORCID: https://orcid.org/0000-0003-1480-3261)
- Javier Crespo (ORCID: https://orcid.org/0000-0001-8248-0172)
- Naroa Goikoetxea‐Usandizaga (ORCID: https://orcid.org/0000-0003-4569-028X)
- César Martı́n (ORCID: https://orcid.org/0000-0002-4087-8729)
- Irene González‐Recio (ORCID: https://orcid.org/0000-0003-1432-8974)
- Ramon A. Bataller (ORCID: https://orcid.org/0000-0002-1119-7799)
- Marina Serrano‐Maciá (ORCID: https://orcid.org/0000-0003-4183-6384)
- Carolina Conter (ORCID: https://orcid.org/0000-0002-5999-8667)
- Mikel Azkargorta (ORCID: https://orcid.org/0000-0001-9115-3202)
- Félix Elortza (ORCID: https://orcid.org/0000-0001-8839-5438)
- D. Buccella (ORCID: https://orcid.org/0000-0002-2266-9026)
- Claudia M. Rejano-Gordillo (ORCID: https://orcid.org/0000-0003-4586-5975)
- José M. Herranz (ORCID: https://orcid.org/0000-0002-6031-535X)
- Irene Díaz‐Moreno (ORCID: https://orcid.org/0000-0002-5318-7644)
- Ramiro Jover (ORCID: https://orcid.org/0000-0002-4914-5804)
- Ute Schaeper (ORCID: https://orcid.org/0000-0003-2556-8391)
- Josepmaria Argemí (ORCID: https://orcid.org/0000-0003-1696-7753)
- Antonio Dı́az-Quintana (ORCID: https://orcid.org/0000-0001-8973-8009)
- Maria Luz Martínez‐Chantar (ORCID: https://orcid.org/0000-0002-6446-9911)
- Leidy Estefanía Zapata-Pavas
- Patricia Peña-Sanfélix
- Armando Ruiz (ORCID: https://orcid.org/0000-0001-8896-8611)
- Luis Alfonso Martínez‐Cruz (ORCID: https://orcid.org/0000-0002-5856-9377)
- Teresa C. Delgado
- Rubén Nogueiras
- Álex Guillamon Thiery
Institutions
- Consejo Superior de Investigaciones Científicas (ES)
- Universitat de València (ES)
- University of the Basque Country (ES)
- Marqués de Valdecilla University Hospital (ES)
- Silence Therapeutics (Germany) (DE)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- CIC bioGUNE (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- University of Pittsburgh Medical Center (US)
- Clinica Universidad de Navarra (ES)
- Centro de Investigaciones Científicas Isla de la Cartuja (ES)
- Instituto de Investigaciones Químicas (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- New York University (US)
- Universitat de Barcelona (ES)
- Universidad de Sevilla (ES)
- Universidad de Extremadura (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Hepatology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1097/hep.0000000000001156
- Citations
- 9
- Primary Topic
- Magnesium in Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.79