Isolation and Characterization of Sesquiterpene Lactones From <i>Syneilesis aconitifolia</i> and Evaluation of Their Anti‐Breast Cancer Activity
Two undescribed sesquiterpene lactones (1 and 2), along with two known analogs (3 and 4), were isolated from Syneilesis aconitifolia. Their structures and absolute configurations were elucidated using spectroscopic analysis, ECD calculations, and single crystal x-ray diffraction. Compound 3 exhibited the highest cytotoxic activity against 4T1 cells, with an IC<sub>50</sub> value of 10.89 µM. In addition, compound 3 significantly induced the apoptosis of 4T1 cells at the concentration of 20 µM. Further anticancer study showed that compound 3 distinctly increased the production of intracellular reactive oxygen species.
Authors
- Desen Yang (ORCID: https://orcid.org/0000-0001-7120-3508)
- C.-G. Zhang
- Mei Zhou (ORCID: https://orcid.org/0000-0003-2576-0252)
- Guoping Gan (ORCID: https://orcid.org/0009-0008-0845-9445)
- kuan lin
- Binlian Sun (ORCID: https://orcid.org/0000-0002-4456-740X)
- Xiji Shu (ORCID: https://orcid.org/0000-0002-7415-6230)
- Lijuan Hu (ORCID: https://orcid.org/0000-0002-6889-1650)
- Xiansheng Ye (ORCID: https://orcid.org/0000-0001-7598-4807)
- Jie Gao (ORCID: https://orcid.org/0000-0003-2021-819X)
- Wei Liu (ORCID: https://orcid.org/0000-0001-8257-0397)
- shuxiu zhu
Institutions
- Hubei University of Chinese Medicine (CN)
- Jianghan University (CN)
- Wuhan Donghu University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1002/cbdv.202402891
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jianghan University