Unraveling bidirectional evolution of unstable mitochondrial DNA mutations in hepatocellular carcinoma at single-cell resolution
Our study unravels the landscape of single-cell somatic mtDNA mutations in HCC tissues and reveals the bidirectional evolution of unstable mtDNA mutations, with potential implications for HCC stratification and therapeutic intervention.
Authors
- Jinliang Xing (ORCID: https://orcid.org/0000-0002-7010-1822)
- Wenjie Song
- Fanfan Xie
- Xiwen Gu (ORCID: https://orcid.org/0000-0002-9575-5654)
- Huanqin Zhang
- Z Q Wang
- Shanshan Guo (ORCID: https://orcid.org/0000-0002-9022-7342)
- Wenjie Guo (ORCID: https://orcid.org/0000-0002-6484-4777)
- Yang Liu (ORCID: https://orcid.org/0000-0003-0045-8380)
- Qing Yuan (ORCID: https://orcid.org/0000-0003-0297-854X)
- Xu Guo (ORCID: https://orcid.org/0000-0003-4902-8859)
- Kaixiang Zhou (ORCID: https://orcid.org/0009-0001-9612-3456)
Institutions
- Northwestern Polytechnical University (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1097/hep.0000000000001113
- Citations
- 6
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.71