Onset and Progression of Disease in Nonhuman Primates With PDE6C Cone Disorder
These data suggest that, like humans, macaque PDE6C heterozygotes are normal, and homozygote primates have absent cone function and reduced foveal ONL thickness from infancy. Cone photoreceptors probably degenerate over time and macular atrophy can occur. Rod photoreceptor function may wane in late stages.
Authors
- Sara M. Thomasy (ORCID: https://orcid.org/0000-0001-5617-9677)
- Lily Nguyen (ORCID: https://orcid.org/0000-0002-8544-684X)
- Ala Moshiri (ORCID: https://orcid.org/0000-0002-4277-8094)
- Jeffrey Rogers (ORCID: https://orcid.org/0000-0002-7374-6490)
- Tim Stout
- Monica Ardon
- Rui Chen (ORCID: https://orcid.org/0000-0002-4387-9735)
Institutions
- Baylor College of Medicine (US)
- Baylor Genetics (US)
- University of California, Davis (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1167/iovs.65.14.16
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- California National Primate Research Center