Vigabatrin‐associated brain magnetic resonance imaging abnormalities and clinical symptoms in infants with tuberous sclerosis complex
VABAM are common in VGB-treated TSC infants; however, VABAM-like abnormalities also occurred in children without either VGB or TSC. The cause of these MRI changes is unknown. Possible contributing factors are abnormal myelination, underlying etiology, recurrent seizures, and other antiseizure medication. Furthermore, the presence of VABAM (or VABAM-like abnormalities) did not appear to be associated with clinical symptoms. This study confirms that the well-known antiseizure effects of VGB outweigh the risk of VABAM and related symptoms.
Authors
- Krzysztof Sadowski (ORCID: https://orcid.org/0000-0002-0730-2226)
- Eleonora Aronica (ORCID: https://orcid.org/0000-0002-3542-3770)
- Kinga Szczepaniak (ORCID: https://orcid.org/0000-0002-0468-1777)
- Floor E. Jansen (ORCID: https://orcid.org/0000-0003-0745-5668)
- Julita Borkowska (ORCID: https://orcid.org/0000-0002-9956-9250)
- Sergiusz Jóźwiak (ORCID: https://orcid.org/0000-0003-3350-6326)
- Rima Nabbout (ORCID: https://orcid.org/0000-0001-5877-4074)
- Willem M. Otte (ORCID: https://orcid.org/0000-0003-1511-6834)
- Anna Jansen (ORCID: https://orcid.org/0000-0002-3835-2824)
- Pavel Kršek (ORCID: https://orcid.org/0000-0002-3071-1589)
- Katarzyna Kotulska (ORCID: https://orcid.org/0000-0002-5015-250X)
- Alexander Leemans (ORCID: https://orcid.org/0000-0002-9306-6126)
- Miroslav Maminak (ORCID: https://orcid.org/0000-0001-9407-9255)
- Alberto De Luca (ORCID: https://orcid.org/0000-0002-2553-7299)
- Jessie De Ridder (ORCID: https://orcid.org/0000-0002-8555-7822)
- Christoph Hertzberg (ORCID: https://orcid.org/0000-0002-5550-8675)
- Maarten H. Lequin (ORCID: https://orcid.org/0000-0001-7488-1734)
- Theresa O. Scholl (ORCID: https://orcid.org/0000-0002-9835-7328)
- Konrad Wojdan (ORCID: https://orcid.org/0000-0002-5627-4858)
- Hanna M. Hulshof (ORCID: https://orcid.org/0000-0003-0122-1174)
- Dorota Domańska‐Pakieła (ORCID: https://orcid.org/0000-0003-4810-4434)
- Jagoda Głowacka‐Walas (ORCID: https://orcid.org/0000-0002-7628-8691)
- Kees P. J. Braun (ORCID: https://orcid.org/0000-0003-3631-0003)
- Martha Feucht (ORCID: https://orcid.org/0000-0001-7691-8158)
- Kamil Sijko (ORCID: https://orcid.org/0000-0002-2203-1065)
- B. Petrák (ORCID: https://orcid.org/0009-0007-2985-9838)
- Paolo Curatolo (ORCID: https://orcid.org/0000-0003-4253-752X)
- Bernhard Weschke (ORCID: https://orcid.org/0000-0003-4533-0743)
- Romina Moavero (ORCID: https://orcid.org/0000-0002-6200-060X)
- Kate Riney
- Lieven G. Lagae (ORCID: https://orcid.org/0000-0002-7118-0139)
- Carmen H. Stevering (ORCID: https://orcid.org/0000-0002-2294-2344)
- Saba Ishrat (ORCID: https://orcid.org/0009-0009-6599-9226)
- David J. Kwiatkowski (ORCID: https://orcid.org/0000-0002-5668-5219)
Institutions
- University of Rome Tor Vergata (IT)
- Brigham and Women's Hospital (US)
- Vrije Universiteit Brussel (BE)
- Harvard University (US)
- University of Antwerp (BE)
- Université Paris Cité (FR)
- Charles University (CZ)
- University Medical Center Utrecht (NL)
- University Hospital in Motol (CZ)
- Amsterdam Neuroscience (NL)
- Children's Memorial Health Institute (PL)
- Bambino Gesù Children's Hospital (IT)
- Transition Technologies (Poland) (PL)
- Institut des Maladies Génétiques Imagine (FR)
- Children's Health Queensland Hospital and Health Service (AU)
- Medical University of Vienna (AT)
- Charité - Universitätsmedizin Berlin (DE)
- University of Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1111/epi.18190
- Citations
- 4
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- European Commission
- Agencja Badań Medycznych