RRM2 Regulates Hepatocellular Carcinoma Progression Through Activation of TGF-β/Smad Signaling and Hepatitis B Virus Transcription
RRM2 is involved in the progression of HCC by activating the TGF-β/Smad signaling pathway. RRM2 increases HBV transcription in HBV-expressing HCC cells. Targeting RRM2 may be of potential value in the treatment of HCC.
Authors
- Zongchao Zuo
- Xin Li (ORCID: https://orcid.org/0000-0002-1450-9241)
- Xinning Sun
- Dong Yan
- Dandan Wu
- Wu Yin
Institutions
- First Affiliated Hospital of Bengbu Medical College (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Genes
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3390/genes15121575
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China