Evaluation of the Efficacy of the Vaccine Production Process in Removing Residual Host Cell DNA from the Vero Cell Rabies Vaccine
The production process described in this study achieved effective recovery of viral antigens and efficient removal of residual HCD, and the process was stable and controllable, enabling the continuous and stable production of vaccine products that meet WHO recommendations and the relevant requirements of the current edition of the Chinese Pharmacopeia. In addition, this study provides theoretical guidance for optimizing the vaccine production process.
Authors
- F Yue (ORCID: https://orcid.org/0000-0002-8357-4717)
- Leitai Shi (ORCID: https://orcid.org/0000-0001-9713-8855)
- Qiang Ye
- Hong‐Xu Chen (ORCID: https://orcid.org/0000-0003-4537-0382)
- Tie Gao
- Shouchun Cao (ORCID: https://orcid.org/0000-0001-6212-260X)
- Danhua Zhao (ORCID: https://orcid.org/0000-0002-1950-4845)
- Xiaohong Wu (ORCID: https://orcid.org/0009-0002-6471-1285)
- Jia Li (ORCID: https://orcid.org/0000-0002-1167-5439)
- Z. Lan
- Ruowen Pan
- Yunpeng Wang (ORCID: https://orcid.org/0009-0000-4296-0454)
Institutions
- National Institutes for Food and Drug Control (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2024-12-06
- DOI
- https://doi.org/10.3390/vaccines12121379
- Citations
- 6
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.30