Topical Application of Dipyridamole and Roflumilast Combination Nanoparticles Loaded Nanoemulgel for the Treatment of Psoriasis in Rats
The new DR-NEG's topical combination administration showed better anti-inflammatory, tissue healing, and anti-psoriatic activity than each drug alone or topical clobetasol administration; this could be attributed to the possible synergic effects of both drugs and the enhanced skin penetration offered by the nanoemulgel formulation.
Authors
- Hayder Adnan Fawzi (ORCID: https://orcid.org/0000-0001-9970-0119)
- Ghada A. Taqa (ORCID: https://orcid.org/0000-0001-9683-7881)
- Alaa A. Abdulqader (ORCID: https://orcid.org/0000-0002-5071-690X)
- Mohamed Ali Lassoued (ORCID: https://orcid.org/0000-0003-2040-3977)
- Majid Sakhi Jabir (ORCID: https://orcid.org/0000-0003-0759-8298)
- Raffah Khamis Mahal
- Zeyad Khalaf Maded
- Souad Sfar
Institutions
- University of Mosul (IQ)
- University of Monastir (TN)
- University of Technology - Iraq (IQ)
- University of Tikrit (IQ)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/ijn.s492180
- Citations
- 8
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.92