Prevalence, correlates and comorbidity of irritability in adults with major depressive episode in the U.S. population (2012–2013)

This study demonstrates a strong association between irritable MDE and psychiatric comorbidities, as well as a substantial burden of depression and related conditions. As a cross-sectional study using a representative sample of the U.S. population with highly reliable psychiatric diagnoses, our results are generalizable. Practitioners managing MDE should identify and treat these comorbidities.