Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis
Our study identifies a pivotal epigenetic ferroptotic pathway that contributes significantly to DOP and uncovers a crucial pharmacological property of AVI that is potentially effective in treating patients with DOP and related osteoporotic disorders.
Authors
- Bin Yang (ORCID: https://orcid.org/0000-0001-7948-3823)
- Binjia Ruan
- Jian Dong (ORCID: https://orcid.org/0000-0001-6333-3724)
- Wangsen Cao (ORCID: https://orcid.org/0000-0001-6209-3482)
- Yongxiang Wang (ORCID: https://orcid.org/0000-0002-2003-6006)
- Guofu Zhang (ORCID: https://orcid.org/0000-0001-9105-0385)
- Fanhao Wei
- Hongwei Wang (ORCID: https://orcid.org/0000-0003-3297-1293)
- Wai Kwok Kelvin Yeung
Institutions
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1016/j.jare.2024.11.036
- Citations
- 26
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 7.41
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- National Key Research and Development Program of China