Molecular Biological Mechanisms of Action of Chrysophanol in Hepatic Stellate Cells Activated by Hepatic B Virus X Based on Network Pharmacology
Thus, our findings indicate that Cho ameliorates HBx-induced HSC activation and liver fibrosis via inhibition of the mTOR and PPARs signaling pathways, suggesting that Cho is a potential therapeutic for chronic liver inflammation-mediated diseases.
Authors
- Yi‐Shiou Chiou (ORCID: https://orcid.org/0000-0002-0436-6603)
- Chan‐Yen Kuo (ORCID: https://orcid.org/0000-0002-5702-5730)
- Ching‐Feng Cheng (ORCID: https://orcid.org/0000-0003-0104-0146)
- Chih-Hung Lin (ORCID: https://orcid.org/0009-0004-4740-0594)
- I.-Kuan Wang
Institutions
- Fu Jen Catholic University (TW)
- Kaohsiung Medical University (TW)
- Tzu Chi University (TW)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Taipei Tzu Chi Hospital (TW)
- Cathay General Hospital (TW)
- Kang-Ning Junior College of Medical Care and Management (TW)
- University of Wisconsin–Milwaukee (US)
Publication Details
- Journal
- Intervirology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1159/000542355
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academia Sinica
- Cathay General Hospital
- Ministry of Science and Technology, Taiwan
- Buddhist Tzu Chi Medical Foundation
- Taipei Tzu Chi Hospital