Photoredox-Catalyst-Free Carboxylation of Unactivated Alkenes in DMSO: Synthesis of Polycyclic Indole Derivatives and Aliphatic Acids
A new method for the carboxylation of unactivated alkenes using CO<sub>2</sub> radical anions in the absence of a photoredox catalyst has been developed. The photocatalyst-free approach enables the efficient synthesis of polycyclic indole derivatives and linear carboxylic acids under mild conditions from HCO<sub>2</sub>K with/without 1,4-diazabicyclo[2.2.2]octane (DABCO) in DMSO. This work demonstrates a significant advance in green chemistry, showcasing a catalyst-free approach for the functionalization of unactivated alkenes with cheap and readily available HCO<sub>2</sub>K.
Authors
- Tsuyoshi Mita (ORCID: https://orcid.org/0000-0002-6655-3439)
- Kosaku Tanaka (ORCID: https://orcid.org/0000-0002-3591-5409)
- Wataru Kanna (ORCID: https://orcid.org/0000-0002-2931-6661)
- Yamato Ueno (ORCID: https://orcid.org/0009-0008-4494-5344)
- Hiroki Hayashi (ORCID: https://orcid.org/0000-0003-2081-6886)
- Suvankar Debbarma (ORCID: https://orcid.org/0000-0002-6467-8764)
Institutions
- Hokkaido University (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1021/acs.orglett.4c04051
- Citations
- 11
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Tokyo Ohka Foundation for The Promotion of Science and Technology
- Japan Society for the Promotion of Science
- Exploratory Research for Advanced Technology