Removing “flavor” from pathogenic antibodies hits a therapeutic sweet spot
Endoglycosidase CU43 removes IgG Fc glycans, inhibits IgG effector functions, and prevents pathology in multiple disease models.
Authors
- Dana L.E. Vergoossen (ORCID: https://orcid.org/0000-0002-7268-9818)
- Maartje G. Huijbers (ORCID: https://orcid.org/0000-0002-6082-5042)
Institutions
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Science Immunology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1126/sciimmunol.adu8805
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00