High Urinary Bisphenol A Levels may be a Risk Factor for Infantile Colic: a case-control study

Objective: To investigate the relationship between infantile colic and urinary Bisphenol A (BPA) levels in infants aged under 3 months. Patients and Method: A group of 20 infants with a recent diagnosis of infantile colic, according to ROMA IV criteria, without treatment and a control group of 33 healthy infants were evaluated. Gestational age, birth weight, age at urine sampling, daily weight gain and consumption of packaged products by the mothers of the infants included in the study were recorded. Urine BPA levels were measured by liquid chromatography-mass spectrometry in an isolated urine sample. Results: The sex, median gestational age, mode of delivery, birth weight, weight at the time of urine sampling, daily weight gain and mother’s packaged product consumption were not significant different between control and colic group. The urine BPA results of infants diagnosed with infantile colic (median 20,4 μg/g/creatinine, IQR 8,9-34,1) were significantly higher than the urine BPA results of the healthy infants (median 9,1 μg/g/creatinine, IQR 4,9-16,3) ( p < 0,05). The model established as a result of the regression analysis was not statistically significant (Model Significance: F = 0,861; p = 0,530; R2 = 0,101). Conclusion: The etiology of infantile colic is still poorly understood and is speculated to be associated with disrupted microbiota. Our results suggest that BPA is associated with the development of infantile colic.