NIR-II Light-Driven Multifunctional Nanozymes PS@CS for Efficient Therapy against Melanoma and Post-tumor Surgery Infection
Melanoma, the most prevalent form of skin cancer, is primarily treated with surgical intervention. However, complete tumor cell removal is challenging, and surgical wounds are prone to infection, complicating treatment and increasing costs. The successful treatment of melanoma generally requires multifunctional agents that are coordinated in tumor therapy and wound healing. In this study, we developed platinum (Pt)- and selenium (Se)-based nanozymes, Pt-Se@Chitosan (PS@CS), which exhibit synergistic antitumor and bactericidal efficacy attributed to their multienzyme activity and strong photothermal conversion efficiency. Furthermore, we engineered PS@CS hydrogels capable of inhibiting tumor regrowth postsurgery and accelerating healing of infected wounds. The PS@CS and PS@CS hydrogels presented herein incorporate characteristics including catalytic therapy, photothermal therapy, antibacterial properties, and skin damage healing, providing an innovative and comprehensive therapeutic approach for melanoma treatment.
Authors
- Xueyang Fang
- Jianing Xu (ORCID: https://orcid.org/0000-0003-2547-4344)
- Hui Ding (ORCID: https://orcid.org/0000-0002-9607-9571)
- Yu-Sung Liang
- Decai Yang
- Beiping Miao (ORCID: https://orcid.org/0000-0003-2307-3280)
- Cuijuan Zhang (ORCID: https://orcid.org/0000-0002-2542-9917)
- Ghulam Abbas (ORCID: https://orcid.org/0000-0001-6318-3893)
- Rui Gong (ORCID: https://orcid.org/0000-0002-5000-1314)
Institutions
- Shenzhen University (CN)
- South China Normal University (CN)
- Chinese Academy of Sciences (CN)
- Chinese PLA General Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Technology University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Qilu Hospital of Shandong University (CN)
- Shenzhen Second People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Nano Letters
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1021/acs.nanolett.4c05389
- Citations
- 6
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Development and Reform Commission of Shenzhen Municipality
- Sanming Project of Medicine in Shenzhen
- Basic and Applied Basic Research Foundation of Guangdong Province