Extracellular nicotinamide phosphoribosyltransferase visfatin activates JAK2-STAT3 pathway in cancer-associated fibroblasts to promote colorectal cancer metastasis
The present work highlights a critical role of visfatin in the crosstalk between CRC cells and CAFs, which moonlight as a non-metabolic extracellular signal molecule to hijacks JAK-STAT pathway in CAFs to promote CRC metastasis.
Authors
- Dan Shu (ORCID: https://orcid.org/0009-0002-0481-3669)
- Jianyu Xia
- Tao Zhang (ORCID: https://orcid.org/0000-0003-4299-3568)
- Yun Lei (ORCID: https://orcid.org/0000-0003-4572-6078)
- He Wei
Institutions
- China National Nuclear Corporation (CN)
- Chengdu Medical College (CN)
- Zhoushan Hospital (CN)
Publication Details
- Journal
- Genes & Genomics
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1007/s13258-024-01596-6
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province