<i>KRAS</i> Variants Are Associated With Survival Outcomes and Genomic Alterations in Biliary Tract Cancers
The adverse impact of <i>KRAS</i> mutations in BTC is driven by G12 alterations in patients with IHC regardless of resection status, which was not observed in GB or EHC. There are unique comutational partners in distinct BTC subsets. These differences have important clinical implications in the era of KRAS-targeted therapeutics.
Authors
- Alice C. Wei (ORCID: https://orcid.org/0000-0002-2505-959X)
- Michael I. D’Angelica (ORCID: https://orcid.org/0000-0002-3731-0534)
- Rebecca G. Gelfer (ORCID: https://orcid.org/0000-0002-7270-8249)
- Hannah L. Kalvin (ORCID: https://orcid.org/0000-0002-6636-0602)
- Wungki Park (ORCID: https://orcid.org/0000-0002-8006-3102)
- Rohit Chandwani (ORCID: https://orcid.org/0000-0003-4781-6069)
- William R. Jarnagin (ORCID: https://orcid.org/0000-0002-1635-5768)
- Mithat Gönen (ORCID: https://orcid.org/0000-0001-8683-8477)
- Kevin C. Soares (ORCID: https://orcid.org/0000-0002-0406-017X)
- Vinod P. Balachandran (ORCID: https://orcid.org/0000-0002-2956-223X)
- James J. Harding (ORCID: https://orcid.org/0000-0002-7029-4310)
- T. Peter Kingham (ORCID: https://orcid.org/0000-0002-3359-3186)
- Aistė Gulla (ORCID: https://orcid.org/0000-0003-2433-3603)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Jeffrey A. Drebin (ORCID: https://orcid.org/0000-0003-2312-2062)
- Ghassan K. Abou‐Alfa (ORCID: https://orcid.org/0000-0002-1522-8054)
- Yi Song (ORCID: https://orcid.org/0000-0003-0125-6019)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Vilnius University (LT)
- Trinity College Dublin (IE)
- Cornell University (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1200/po.24.00263
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health