Influence of Epithelial-Mesenchymal Transition on Risk of Relapse and Outcome to Eribulin or Cyclin-Dependent Kinase Inhibitors in Metastatic Breast Cancer
We demonstrate in our exploratory study that biomarkers involved in the process of EMT could have a prognostic impact in a cohort of patients with BC uniformly treated and with long-term follow-up. Genes known to be involved in EMT were associated with improved eribulin efficacy, while suggesting a poorer outcome with CDK4/6i.
Authors
- Natali Vasilevski (ORCID: https://orcid.org/0000-0002-6146-7937)
- Arlene Chan (ORCID: https://orcid.org/0000-0003-2135-2286)
- Sarah Christine Elisabeth Wright (ORCID: https://orcid.org/0000-0003-3715-6677)
- Jespal Gill
- Pieter J.A. Eichhorn (ORCID: https://orcid.org/0000-0001-5840-943X)
- HuiJun Chih (ORCID: https://orcid.org/0000-0001-9294-0996)
Institutions
- Curtin University (AU)
- Pathwest Laboratory Medicine (AU)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1200/po.24.00274
- Citations
- 4
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Eisai