Feasibility of Simon 2-Stage Futility Trials in Early Parkinson Disease
Based on our analysis of DATATOP and PRECEPT, phase 2 clinical trials using the Simon 2-Stage methodology are feasible in PD and may offer an opportunity to expedite the discovery of promising treatments in early PD.
Authors
- Michael G. Schlossmacher (ORCID: https://orcid.org/0000-0002-0394-0300)
- Jop Mostert (ORCID: https://orcid.org/0000-0003-3640-9935)
- Marcus Koch (ORCID: https://orcid.org/0000-0001-9972-5092)
- Daryl Wile (ORCID: https://orcid.org/0000-0002-5341-9062)
- Bernard M.J. Uitdehaag (ORCID: https://orcid.org/0000-0002-9226-7364)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Amber R. Salter (ORCID: https://orcid.org/0000-0002-1088-110X)
- Gary Cutter (ORCID: https://orcid.org/0000-0002-8455-980X)
- Tiago Mestre (ORCID: https://orcid.org/0000-0002-6973-7479)
- Lorraine V. Kalia (ORCID: https://orcid.org/0000-0002-9384-1305)
- Justyna R. Sarna (ORCID: https://orcid.org/0000-0003-3308-1540)
Institutions
- University of Calgary (CA)
Publication Details
- Journal
- Neurology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1212/wnl.0000000000210079
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74