Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults
This study highlights the variability in physical and cognitive performance among older adults and suggests that neuroimaging markers of neurodegeneration, cSVD, and microstructural WM integrity may account for these variations. Our findings indicate the potential for developing group-based strategies to prevent and manage age-related functional decline. Further research with larger sample sizes is needed to deepen our understanding of physical-cognitive decline patterns.
Authors
- Sara Shams (ORCID: https://orcid.org/0000-0002-5133-0224)
- Olof E. Lindberg (ORCID: https://orcid.org/0000-0001-6352-108X)
- Miia Kivipelto (ORCID: https://orcid.org/0000-0003-0992-3875)
- Mana Shams (ORCID: https://orcid.org/0009-0003-9066-6470)
- Anna Zettergren (ORCID: https://orcid.org/0000-0002-7182-8417)
- Ingmar Gr. Skoog (ORCID: https://orcid.org/0000-0002-9803-3438)
- Anna Marseglia (ORCID: https://orcid.org/0000-0002-9672-6978)
- Silke Kern (ORCID: https://orcid.org/0000-0001-7617-7214)
- Eric Westman (ORCID: https://orcid.org/0000-0002-3115-2977)
- Johan Skoog (ORCID: https://orcid.org/0000-0001-9549-5875)
- Therese Rydberg Sterner (ORCID: https://orcid.org/0000-0001-8202-8522)
- Joana B. Pereira (ORCID: https://orcid.org/0000-0002-4604-2711)
- Rui Wang (ORCID: https://orcid.org/0000-0001-7209-741X)
Institutions
- Swedish School of Sport and Health Sciences (SE)
Publication Details
- Journal
- Neurology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1212/wnl.0000000000210121
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Parkinson's Foundation
- Hjärnfonden
- Karolinska Institutet
- Stockholms Läns Landsting
- Vetenskapsrådet
- Alzheimerfonden
- Parkinsonfonden
- Center for Innovative Medicine