DETAILED ELECTROCHEMICAL BEHAVIOR INVESTIGATION AND DETERMINATION OF ANTIPSYCHOTIC DRUG PALIPERIDONE ON A GLASSY CARBON ELECTRODE

Objective: A sensitive and cost-effective electrochemical method was developed on a bare glassy carbon electrode (GCE) for the determination of paliperidone (PAL), an antipsychotic drug used in the primary schizophrenia treatment affecting the whole world. Material and Method: The oxidation studies carried out in pH 8 phosphate buffer solution (PBS) by cyclic voltammetry (CV) showed that the oxidation reaction of PAL is a process including the same number of electrons and protons. The electrochemical detection of PAL was carried out by differential pulse voltammetry (DPV). Result and Discussion: The linearity range was between 1 µM and 100 µM. The limit of detection (LOD) and quantification (LOQ) values were calculated as 2.41x10-7 M and 8.033x10-7 M, respectively. The applicability of the developed method was confirmed by using it on synthetic human serum. The relative standard deviation (RSD) values were less than 2%. The selectivity of the analysis was demonstrated over against interfering substances such as ascorbic acid, KNO3, MgCl2, paracetamol, dopamine, Na2SO4, and uric acid with recovery% and RSD% values in the range 98.32%-101.56% and 0.15%-1.99%, respectively. The proposed method provided high sensitivity for PAL and is the first reported method for the electroanalysis of PAL.