Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer
This study uncovers a paracrine mechanism of chemoresistance in PCa and proposes that targeting the stroma could be a therapeutic choice.
Authors
- Shirong Peng (ORCID: https://orcid.org/0000-0001-8905-3317)
- Yining Li (ORCID: https://orcid.org/0009-0003-7613-2659)
- Hai Huang (ORCID: https://orcid.org/0000-0002-2013-073X)
- Bingheng Li
- Junjia Xie
- Zean Li
- Kaiwen Li (ORCID: https://orcid.org/0000-0002-6460-5768)
- Shun-Li Yu
- Zhi Xiong (ORCID: https://orcid.org/0000-0002-8709-6150)
- Zhaoxiang Xie
- Ruilin Zhuang
Institutions
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1016/j.jare.2024.12.003
- Citations
- 21
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.99
Funders
- Guangzhou Medical University
- Bethune Charitable Foundation
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Fundamental Research Funds for the Central Universities