Exploring the therapeutic potential of avocado oil: Insights into obesity metabolism and immune regulation through in vitro models

Avocado oil boasts a compelling nutritional profile characterized by a richness of unsaturated fatty acids and key lipophilic compounds. This study aimed to explore the potential of avocado oil in obesity-related metabolic processes and immune responses modulation in in vitro cellular models. Results obtained unveiled avocado oil capacity to effectively regulate triglyceride accumulation in differentiated 3T3-L1 adipocytes, showcasing a remarkable five-fold increase in adipolysis rate at 15 mg/mL, and an increase in glucose uptake in insulin-stimulated cells. Furthermore, avocado oil exhibited significant immunomodulatory effects in IL-1β-stimulated Caco-2 cells, as it reduced IL-6 (by 11%) and IL-8 (by 12%) production at 10 mg/mL, while only a marginal uptick in TNF-α secretion was observed at the same concentration. These findings underscore the potential of avocado oil to be a beneficial component in functional foods and nutraceuticals targeted at obesity management. • Avocado oil showed a high cellular antioxidant capacity. • Avocado oil enhances the rate of lipolysis. • Avocado oil promotes increased glucose uptake under insulin stimulation. • Avocado oil effectively modulates immune response in gut cells.