Indoxyl Sulfate and Its Potential Role in Mineralocorticoid Receptor Transactivation in Chronic Kidney Disease
IS could enhance MR transactivation by increasing MR protein levels through oxidative stress in CKD rats, indicating that treatment with MR antagonists and antioxidants may play a permissive role in inhibiting IS-induced CKD progression.
Authors
- Koro Gotoh (ORCID: https://orcid.org/0000-0003-3190-1146)
- Hirotaka Shibata (ORCID: https://orcid.org/0000-0001-6506-4820)
- Akihiro Fukuda
- Akiko Kudo
Institutions
- Oita University (JP)
- Oita University of Nursing and Health Sciences (JP)
Publication Details
- Journal
- Cureus
- Published
- 2024-12-06
- DOI
- https://doi.org/10.7759/cureus.75236
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00