Antiviral immunity lassoed down by excess RNA
Two complementary works by Chan et al. (https://doi.org/10.1084/jem.20231725), and Ru et al. (https://doi.org/10.1084/jem.20240010), identify defective RNA processing as the root cause of impaired antiviral immunity against SARS-CoV2 in the human brainstem. These studies provide molecular insight into virus-associated severe brainstem encephalitis through PKR inactivation.
Authors
- Anna Kajaste‐Rudnitski (ORCID: https://orcid.org/0000-0003-1549-2426)
- Erika Valeri (ORCID: https://orcid.org/0009-0008-4358-1403)
Institutions
- Research Institute of Molecular Pathology (AT)
- University of Pavia (IT)
- The San Raffaele Telethon Institute for Gene Therapy (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1084/jem.20241743
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- European Research Council