Cortex kidney tissue partial oxygen pressure depends on percentage of active oxygenation during oxygenated hypothermic machine perfusion
This study demonstrates that continuous HMPO<sub>2</sub> results in a significant modification of tpO<sub>2</sub> compared with SCS, and the degree of tpO<sub>2</sub> is positively correlated with the percentage of active oxygenation during HMP. Metabolic profile analyses (ATP resynthesis) suggest that the aerobic mechanism is better supported with higher oxygen levels (50% and 100% oxygenation).
Authors
- Julien Branchereau (ORCID: https://orcid.org/0000-0002-8460-9352)
- David Minault
- Jérémy Hervouet
- Thomas Prudhomme (ORCID: https://orcid.org/0000-0003-3601-9339)
- Philipp Kron (ORCID: https://orcid.org/0000-0002-6074-7072)
- Gilles Blancho
- Tom Darius (ORCID: https://orcid.org/0000-0002-8151-4286)
- Sarah Bruneau (ORCID: https://orcid.org/0000-0002-1552-0725)
- S. Lévy (ORCID: https://orcid.org/0009-0002-8383-0108)
- Emma Loiseau (ORCID: https://orcid.org/0009-0006-7034-5268)
- Benoît Mesnard (ORCID: https://orcid.org/0000-0002-3314-1892)
- Stéphanie Le Bas‐Bernardet (ORCID: https://orcid.org/0000-0002-3751-9848)
- Lionel Badet (ORCID: https://orcid.org/0000-0002-9596-0279)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Inserm (FR)
- University Hospital of Zurich (CH)
- Institut de Transplantation Urologie en Nephrologie (FR)
- Center for Research in Transplantation and Translational Immunology
- UCLouvain (BE)
- Nantes Université (FR)
Publication Details
- Journal
- Artificial Organs
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1111/aor.14916
- Citations
- 1
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Agence de la Biomédecine
- Association Française d'Urologie