Longitudinal Imaging Biomarkers Correlate with Progressive Motor Deficit in the Mouse Model of Charlevoix‐Saguenay Ataxia
We show that both RNFL thickening and MRI changes may represent biomarkers of disease progression in the Sacs<sup>-/-</sup> mouse model. Our data gathers knowledge instrumental to clinical studies, holding potential as readout for treatment efficacy. ANN NEUROL 2025;97:425-434.
Authors
- Valerio Castoldi (ORCID: https://orcid.org/0000-0002-8136-3422)
- Angelo Quattrini (ORCID: https://orcid.org/0000-0002-8226-8320)
- Paola Podini (ORCID: https://orcid.org/0000-0002-4757-9887)
- Su‐Chun Huang (ORCID: https://orcid.org/0000-0002-7359-6736)
- Letizia Leocani (ORCID: https://orcid.org/0000-0001-9326-6753)
- Valentina Gigliucci (ORCID: https://orcid.org/0000-0001-8760-3741)
- Francesca Maltecca (ORCID: https://orcid.org/0000-0001-8095-8208)
- Sirio Cocozza (ORCID: https://orcid.org/0000-0002-0300-5160)
- Alessandra Scaravilli (ORCID: https://orcid.org/0000-0001-6375-5783)
- Giorgio Boschetti
Institutions
- Vita-Salute San Raffaele University (IT)
- IRCCS Ospedale San Raffaele (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1002/ana.27146
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Ministero della Salute