Dynamics of the blood plasma proteome during hyperacute HIV-1 infection
The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levels with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.
Authors
- Pontiano Kaleebu (ORCID: https://orcid.org/0000-0001-9706-2977)
- Sven Kjellström (ORCID: https://orcid.org/0000-0003-4646-5279)
- Kamini Gounder (ORCID: https://orcid.org/0000-0002-1674-6021)
- Matt A. Price (ORCID: https://orcid.org/0000-0002-2918-1373)
- Tirthankar Mohanty (ORCID: https://orcid.org/0000-0003-4593-9612)
- Emil Johansson (ORCID: https://orcid.org/0000-0002-4712-3687)
- Etienne Karita (ORCID: https://orcid.org/0000-0001-9475-5436)
- Joakim Esbjörnsson (ORCID: https://orcid.org/0000-0002-3822-4953)
- Sarah Rowland‐Jones (ORCID: https://orcid.org/0000-0001-5788-6998)
- Eric Hunter (ORCID: https://orcid.org/0000-0002-4273-8631)
- Thumbi Ndung’u (ORCID: https://orcid.org/0000-0003-2962-3992)
- Eduard J. Sanders (ORCID: https://orcid.org/0000-0002-1062-8921)
- Eva Freyhult (ORCID: https://orcid.org/0000-0003-0226-1047)
- Jamirah Nazziwa (ORCID: https://orcid.org/0000-0001-9029-7976)
- Jonathan Hare (ORCID: https://orcid.org/0000-0002-1861-4815)
- Amin S. Hassan (ORCID: https://orcid.org/0000-0001-5296-4264)
- William Kilembe (ORCID: https://orcid.org/0000-0002-9012-7325)
- Jill Gilmour
- Melinda Rezeli (ORCID: https://orcid.org/0000-0003-4373-5616)
- Filip Årman
- Mun‐Gwan Hong
- Anatoli Kamali
- Susan Allen
Institutions
- Uppsala University (SE)
- Centre for Infectious Disease Research in Zambia (ZM)
- International AIDS Vaccine Initiative (US)
- Emory University (US)
- Stockholm University (SE)
- University of California, San Francisco (US)
- Lund University (SE)
- Science for Life Laboratory (SE)
- Ragon Institute of MGH, MIT and Harvard (US)
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- Aga Khan University Nairobi (KE)
- Kenya AIDS Vaccine Initiative (KE)
- Aurum Institute (ZA)
- Africa Health Research Institute (ZA)
- Oxford BioMedica (United Kingdom) (GB)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- Imperial College London (GB)
- Uganda Virus Research Institute (UG)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1038/s41467-024-54848-0
- Citations
- 3
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- United States Agency for International Development
- International AIDS Vaccine Initiative
- Lunds Universitet
- Svenska Sällskapet för Medicinsk Forskning
- Vetenskapsrådet
- National Institutes of Health
- Medical Research Council
- Medicinska Fakulteten, Lunds Universitet