Systems Immunology Approaches to Understanding Immune Responses in Acute Infection of Yellow Fever Patients
In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical and immunological data to decode the pathogenesis of YF. Analyzing 79 patients, we found distinct gene expression patterns between acute YF, other viral infections, and the milder YF-17D vaccine infection. We identified a critical role for low-density, immature neutrophils in severe outcomes, marked by the downregulation of genes essential for neutrophil migration and maturation, such as PADI4, CSF3R, and ICAM1, in deceased patients. Our study also revealed complex interactions among inflammation-related genes, including increased CXCL10 and IL1R2 expression and decreased IL-1b expression in the acute phase. The diminished expression of HLA class II genes indicates impaired antigen presentation. These findings highlight the delicate balance of immune responses in YF pathogenesis and lay the groundwork for future therapeutic and diagnostic advancements.
Authors
- Otávio Cabral-Marques (ORCID: https://orcid.org/0000-0002-3183-6236)
- Alvina Clara Félix (ORCID: https://orcid.org/0000-0002-6084-8172)
- Priscilla R. Costa (ORCID: https://orcid.org/0000-0001-6812-4999)
- Natália B. Cerqueira
- Helder I. Nakaya (ORCID: https://orcid.org/0000-0001-5297-9108)
- Alvino Maestri (ORCID: https://orcid.org/0000-0002-7372-3520)
- Vanessa Escolano Maso (ORCID: https://orcid.org/0000-0003-4108-0206)
- Frederico Moraes Ferreira (ORCID: https://orcid.org/0000-0002-7403-9165)
- José Deney Alves Araújo (ORCID: https://orcid.org/0000-0001-6239-3493)
- Rafick‐Pierre Sékaly (ORCID: https://orcid.org/0000-0002-7816-4828)
- Daniela M. Ferreira (ORCID: https://orcid.org/0000-0002-0594-0902)
- Patrícia Gonzalez‐Dias (ORCID: https://orcid.org/0000-0002-6434-3841)
- Renata Buccheri (ORCID: https://orcid.org/0000-0002-3217-5898)
- Juliana Zanatta de Carvalho Dias (ORCID: https://orcid.org/0000-0001-7894-5803)
- Mateus Vailant Thomazella (ORCID: https://orcid.org/0000-0002-1527-6910)
- Esper Georges Kallas (ORCID: https://orcid.org/0000-0003-2026-6925)
- Cássia Gisele Terrassani Silveira (ORCID: https://orcid.org/0000-0002-0932-7769)
- Carolina Argondizo Correia (ORCID: https://orcid.org/0000-0003-4526-0896)
- Carlos Henrique Valente Moreira (ORCID: https://orcid.org/0000-0002-4187-5482)
- André N. A. Gonçalves (ORCID: https://orcid.org/0000-0001-5264-8368)
- Mariana Prado Marmorato (ORCID: https://orcid.org/0000-0002-0644-0862)
- Amanda Pereira Vasconcelos (ORCID: https://orcid.org/0000-0003-1684-0509)
- Felipe M. Martins (ORCID: https://orcid.org/0000-0001-8170-2263)
- Adam‐Nicolas Pelletier
- Jordana Grazziela Alves Coelho-dos-Reis
Institutions
- Universidade Federal de Minas Gerais (BR)
- Emory University (US)
- Universidade de São Paulo (BR)
- Hospital Israelita Albert Einstein (BR)
- Instituto de Infectologia Emílio Ribas (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Oxford BioMedica (United Kingdom) (GB)
- Exfo Electro-Optical Engineering (Canada) (CA)
Publication Details
- Journal
- Journal of Medical Virology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/jmv.70099
- Citations
- 6
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 3.26